In what way is the making of a primary lysosome similar to the enzymes delivered by the pancreas?

The production of a primary lysosome shares similarities with the enzymes delivered by the pancreas in that both are synthesized by membrane-bound polyribosomes. In eukaryotic cells, membrane-bound polyribosomes are responsible for translating mRNA that codes for proteins destined for secretion or for insertion into membranes, such as the enzymes produced by the pancreas, which are important for digestion. Similarly, the enzymes within primary lysosomes are synthesized in this manner, as lysosomal enzymes are produced in the rough endoplasmic reticulum, where they are initially synthesized as precursors before being packaged into vesicles and transported to the lysosome.

This commonality in their production highlights a critical aspect of cellular function in utilizing ribosomes attached to membranes to direct the synthesis of proteins that play vital roles in cell metabolism and digestion. The other options do not reflect the same process: for example, the enzymes from the pancreas are not activated by pH changes in the stomach prior to being made; rather, they are secreted in an inactive form and then activated in the intestine, making that option inaccurate. Similarly, both lysosomal enzymes and pancreatic enzymes are not activated or stored in the same manner, nor do they have the same components when considered at the molecular level,