Which cells are primarily responsible for inflammation signaling?

Mast cells play a crucial role in inflammation signaling, primarily due to their capacity to release histamine and other mediators when activated. These cells are found in various tissues throughout the body and are key players in the immune response, particularly in allergic reactions and defense against pathogens. When tissues are injured or infected, mast cells degranulate, releasing substances that contribute to the inflammatory response. This includes increasing blood flow, increasing vascular permeability, and attracting other immune cells to the site of injury or infection, amplifying the body's defensive mechanisms.

While macrophages also contribute significantly to inflammation by secreting cytokines and phagocytizing pathogens, mast cells are influential at the initial stages of the inflammatory response. Fibroblasts and adipocytes do not primarily function in signaling for inflammation; fibroblasts are associated with tissue repair and structure, and adipocytes are primarily involved in energy storage. Thus, the role of mast cells in initiating and regulating the inflammatory response underscores their significance in this process.